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VPN environments require that the VPN tunnel not be optimized. When you configure the acceleration policy, add a pass-through rule for the endpoint client VPN port number. This rule must be the first rule on the list.
The Mobile Client has been tested with the following VPN software:
| VPN Client Version | VPN Hardware Model | Notes |
| Cisco VPN Client 4.8 | Cisco PIX 501, Cisco ASA 5000 | |
| Cisco VPN Client 5.0 | Cisco PIX 501, Cisco ASA 5000 | |
| Juniper Networks Connect 5.4 | Juniper Secure Access 700 | |
| Juniper Networks Connect 5.5 | Juniper Secure Access 700 | |
| Nortel Contivity Client 5.01 | Nortel VPN Router 600 | |
| Juniper Networks NetScreen Remote VPN Client 8.5 | Juniper Networks NetScreen-5GT | XP only |
| OpenVPN Solutions LLC OpenVPN Client 2.0.7 | ||
| Microsoft Windows PPTP client |